abstract |
The present invention relates to an antibody against interleukin-4 receptor α (IL-4Rα) or an antigen-binding fragment thereof, and their use in therapy, treatment of diseases related to IL-4R, IL-4 and / or IL-13. Or providing for therapeutic use for prevention. An isolated antibody or antigen-binding fragment thereof that specifically binds to an epitope comprising human IL-4Rα loop 2 L67 and L68 and loop 3 D92 and V93. The epitope includes L67 and L68 of loop 2 and D92 and V93 of loop 3, and the epitope further includes V65-H72 of loop 2 and L89-N98 of loop 3 or a part thereof. An isolated antibody or antigen-binding fragment thereof. [Selection figure] None |