http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017086017-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2d7cb5f2fae194f2c4de9f232397e8de http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_49f04b1dc6b9fcc2d8b159c5ebee364b |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-84 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2015-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b29659db37ebcfcddf2ed8a5e37548d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e93653734ee2966a82d246b378abb1a9 |
| publicationDate | 2017-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2017086017-A |
| titleOfInvention | Method for determining Ca2 + inflow pathway into cytoplasm suppressed by anti-inflammatory substance |
| abstract | An object of the present invention is to provide a method for simply determining the action mechanism of an anti-inflammatory action by an anti-inflammatory substance. A method of stimulating leukocytes or leukocyte-like cultured cells responsible for innate immunity with a sarcoplasmic reticulum / endoplasmic reticulum Ca 2+ ATPase inhibitor in a state where the extracellular fluid is Ca 2+ free, and in the presence of an anti-inflammatory substance And in the absence, the step of increasing the Ca2 + concentration of the extracellular fluid, the step of measuring the cytoplasmic Ca2 + concentration and superoxide production amount of the cultured cells, and the anti-inflammatory substance compared to the absence of the anti-inflammatory substance When the cytoplasmic Ca 2+ concentration in the presence of Cd decreases and the amount of superoxide produced decreases, the Ca 2+ influx pathway into the cytoplasm suppressed by anti-inflammatory substances is the store-operated calcium influx (SOCE) pathway. Determining that there is a method. [Selection figure] None |
| priorityDate | 2015-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 82.