http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017079761-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_82ae8798cdec6cc8f8ad3eb62813831e |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-331 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-533 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
| filingDate | 2016-12-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bee051eab24f930d690d1cc3e89f961a |
| publicationDate | 2017-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2017079761-A |
| titleOfInvention | Compositions and methods for specific inhibition of gene expression by dsRNA with modifications |
| abstract | The present invention provides a composition for specific inhibition of gene expression by dsRNA having modifications. An isolated double-stranded RNA (dsRNA) comprising: i) a sense strand having a length of 19 to 80 nucleotides; and ii) an antisense strand having a length of 19 to 35 nucleotides. The sense strand and the antisense strand form a duplex of 15-35 base pairs in length; the sense strand includes a tetraloop adjacent to the duplex, and the tetraloop is 2 ′ -Containing at least one nucleotide with a sugar substitution; said dsRNA comprising a discontinuity between the 5 'end of said sense strand and the 3' end of said antisense strand; and said dsRNA in mammalian cells An isolated dsRNA that reduces target gene expression. The tetraloop is a dsRNA having a nucleic acid sequence selected from UNCG, GNRA, CUUG, d (GNNA), d (GNAB), d (CNNG) and d (TNCG). [Selection] Figure 1A |
| priorityDate | 2008-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 445.