| abstract |
Carbonate prodrugs and methods of using the same are provided. The present invention provides carbonate prodrugs comprising a carbonic anhydride phosphate prodrug moiety attached to a hydroxyl or carboxyl group of a parent drug moiety. The prodrug may have improved physicochemical properties compared to the parent drug. Also provided are methods of treating diseases or conditions that are responsive to the parent drug using carbonate prodrugs, as well as kits and unit doses. One aspect is a compound attached to the parent drug moiety at (a) a parent drug moiety that includes a hydroxyl group or a carboxyl group, or both, and (b) a hydroxyl group and / or carboxyl group that provides a carbonate moiety. Prodrugs comprising a prodrug moiety of —C (O) O—P (O) (OH) 2 , or a pharmaceutically acceptable salt thereof or a solvate of the foregoing are provided. [Selection] Figure 3 |