| abstract |
An adenine nucleotide translocator (ANT) ligand capable of inducing apoptosis or a similar cell death mechanism, and a pharmaceutical composition containing the ligand. An ANT-ligand having a pyrimidine compound of formula (I) and a pharmaceutical composition having formula I. [R1 is-(CH2) n-CO-OH,-(CH2) n-C3-C6 cycloalkyl group,-(CH2) n-Het,-(CH2) n-NH-CO-R,-(CH2) n-NH2, or-(CH2) n-NH-CO-OH, etc .; R2 is-(CH2) n-Ar or-(CH2) n-CO-OH, etc .; R3 is two adjacent carbon atoms of the pyrimidinone ring To form a thienyl ring group] [selection figure] None |