| abstract |
A novel synthetic approach for preparing tetracycline analogs is provided. Tetracyclines antibiotics have played an important role in the treatment of infections over the past 50 years. However, as the use of tetracycline in medicine and veterinary medicine has increased, resistance has developed among many organisms that were previously sensitive to tetracycline antibiotics. The modular synthesis of the described tetracyclines and tetracycline analogs provides an efficient and enantioselective pathway for various tetracycline analogs and polycyclines that were once inaccessible by previous tetracycline synthesis and semi-synthetic methods. These analogs can be used as antibacterial or antiproliferative agents in treating human or other animal diseases. [Selection figure] None |