| abstract |
An anti-TGFbetaRII immunoglobulin single variable domain is provided. An anti-TGFbetaRII immunoglobulin single variable domain has a specific amino acid sequence with up to 5 amino acid substitutions, deletions or additions, and is associated with TGFbeta signaling. Preferably, tissue fibrosis such as pulmonary fibrosis such as idiopathic pulmonary fibrosis; liver fibrosis such as cirrhosis and chronic hepatitis; rheumatoid arthritis; eye disorders; cutaneous fibrosis such as keloid skin; Polypeptides and pharmaceutical compositions for treating diseases selected from the group of vascular pathologies such as renal fibrosis, such as nephritis and nephrosclerosis; wound healing; reduction of scarring; and restenosis. [Selection figure] None |