| abstract |
Disclosed is a therapeutic agent that enables control of LDL cholesterol levels. An immunogen comprising at least one antigenic PCSK9 peptide linked to an immunogenic carrier, wherein the antigenic PCSK9 peptide consists of a specific amino acid sequence. The immunogen as described above, wherein the immunogenic carrier is selected from diphtheria toxin, CRM197, or VLP selected from HBcAg, HBsAg, Qbeta, PP7, PPV, or Norwalk virus VLP. [Selection figure] None |