abstract |
[PROBLEMS] To have mPGES-1 inhibitory activity, pain, rheumatism, osteoarthritis, fever, Alzheimer's disease, multiple sclerosis, arteriosclerosis, glaucoma, ocular hypertension, ischemic retinal disease, systemic scleroderma And / or a compound useful for the prevention or treatment of malignant tumors including colorectal cancer. A triazine compound represented by the formula [I-a], [I-b] or [I-c], or a pharmaceutically acceptable salt thereof. [R1 is C1-4 alkyl or C3-7 cycloalkane substituted methyl; R2 and R3 are each independently H etc .; R4 is isopropyl etc .; R5 is C1-6 alkyl; R6 is C1-6 Alkyl etc .; X is CH2 or O] [Selection] None |