| abstract |
An H3 type equine influenza A virus is provided. The present invention provides an isolated H3 type equine influenza A virus. It is isolated from a foal that dies from fatal pneumonia, and the virus has characteristic substitutions at residues 78 and 159 of HA (position numbering is done with the mature protein lacking the 15 amino acid signal peptide) Have That is, the residue at position 78 of HA is not valine and the residue at position 159 is not asparagine. In one embodiment, an isolated H3 influenza A virus of the invention is a conservative substitution at residue 78, such as a valine to alanine substitution, and a non-conservative substitution at residue 159, such as from aspartic acid. Has serine substitution. [Selection figure] None |