| abstract |
Disclosed is a preparation for transdermal administration that reduces the amount of problematic buprenorphine accompanied by skin irritation and is effective for a long period of time. A) a buprenorphine impermeable backing layer, and B) a buprenorphine-containing pressure sensitive adhesive layer on the buprenorphine impermeable backing layer, wherein the adhesive layer is a) at least one polymer-based backing layer. Pressure sensitive adhesive, b) buprenorphine base or an equimolar amount of a pharmaceutically acceptable salt thereof, and c) buprenorphine is solubilized therein to form a mixture, and the buprenorphine carboxylate mixture is said pressure sensitive adhesive A buprenorphine-containing adhesive comprising a sufficient amount of a carboxylic acid selected from the group consisting of oleic acid, linoleic acid, linolenic acid, levulinic acid, and mixtures thereof to form a deposit dispersed therein A buprenorphine comprising a layer structure, wherein the buprenorphine-containing pressure sensitive adhesive layer is a skin contact layer Skin formulations for administration. [Selection figure] None |