| abstract |
The present invention provides compositions and methods for treating or preventing breast cancer in humans. In certain aspects, the present invention provides compositions and methods for treating or preventing breast cancer in humans. In part, this disclosure relates to the use of activin antagonists and ActRIIa antagonists to treat or prevent breast cancer or breast cancer-related bone loss. In particular, the present disclosure provides a method for treating or preventing breast cancer using a soluble form of ActRIIa that acts as an inhibitor of activin. Soluble ActRIIa can affect cancer cell growth or survival by mechanisms other than activin antagonism, but nevertheless desirable therapeutic agents may be selected based on activin antagonism or ActRIIa antagonism or both it can. [Selection figure] None |