abstract |
As a tool for drug delivery, polypeptide stability and in vivo half-life extension or regulation of albumin derivatives and variants, and / or fusion polypeptides comprising such albumin derivatives and variants Providing usage. The albumin derivative or variant, fragment thereof, or a fusion polypeptide comprising the albumin derivative or variant or fragment thereof, wherein the albumin derivative or variant or fragment thereof comprises (i) an albumin domain III or a derivative or variant thereof and (ii) at least one further albumin domain selected from albumin domains I and II or a fragment, derivative or variant thereof, or (i) and (ii) Wherein the albumin derivative or variant is not a natural albumin derivative or variant, but an albumin derivative or variant, fragment or fusion polypeptide thereof. [Selection figure] None |