| abstract |
A novel bispecific antigen-binding molecule for T-cell activation and a polynucleotide encoding the bispecific antigen-binding molecule, vector, host cell, produced by redirecting to a specific target cell, And a method for producing the bispecific antigen-binding molecule and a method for use in the treatment of diseases. A Fab molecule capable of specifically binding to an activated T cell antigen that is a first antigen-binding portion, and a target cell antigen that is capable of specifically binding to a second antigen-binding portion. A T cell activated bispecific antigen binding molecule comprising a Fab molecule and an Fc domain consisting of first and second subunits capable of stable association, said first antigen binding moiety comprising: A) a single chain Fab molecule in which the Fab light chain and Fab heavy chain are linked by a peptide linker, or (b) a crossover Fab molecule in which either the variable or constant region of the Fab light chain and Fab heavy chain is exchanged. A T cell activated bispecific antigen binding molecule. [Selection figure] None |