| abstract |
A TWEAK-binding antibody is provided. Anti-TWEAK antibodies have been described. This anti-TWEAK antibody can be used to treat a variety of conditions and diseases, such as, for example, inflammatory diseases, neuronal cell diseases, or other diseases described herein. When used to treat a human subject, the antibody is a human antibody, a humanized antibody, or other substantially human antibody. In one aspect, the disclosure features a protein that binds to TWEAK, such as human TWEAK, including sequences of first and second immunoglobulin variable regions. This protein, for example, less than 10 -7 M, for example, bind to TWEAK an affinity corresponding to 10 -8 M, 10 -9 M, 10 -10 M, 10 -11 M or more a K D be able to. [Selection figure] None |