| abstract |
【Task】 To deliver a single multiparticulate dosage form that delivers one or more basic active drug ingredients into the body in need of the drug to achieve a target PK (pharmacokinetic) profile. [Solution] The present invention relates to unit multiparticulate dosage forms comprising one or more multilayer coated drug particles (beads, pellets, mini-tablets / micro-tablets) having a barrier coating and a delay coating. Each timed pulsed release (TPR) bead population exhibits different release characteristics after exhibiting a predetermined delay time. The composition and thickness of the barrier coating, the composition and thickness of the delay coating, the ratio of IR beads to one or more TPR bead populations, and the total dosage are determined by the alkalinity, pH-dependent solubility and excretion of the active ingredient Depending on the half-life, a target PK profile (suitable for once or twice daily dosing regimens) in patients in need of such drugs can be achieved. [Selection] Figure 1 |