| abstract |
The present invention provides a transdermal preparation containing testosterone and having high skin tolerance, efficient and controlled skin absorption. A permeation enhancing system comprising 2% by weight of testosterone and a C2-C4 alkanol, a polyhydric alcohol, and a monoalkyl ether of diethylene glycol, comprising substantially a long-chain fatty alcohol, a long-chain fatty acid and a long-chain fatty acid ester. Transdermal or transmucosal preparations that are not included. Further, a transdermal or transmucosal preparation comprising at least one of a gelling agent, a neutralizing agent, a chelating agent or a solution, or a combination thereof. 5 to 50% by weight of alkanol, 1 to 30% by weight of polyhydric alcohol, 0.2 to 25% by weight of permeation enhancer, 0.05 to 4% by weight of gelling agent, 0.05 to 0.05% of neutralizing agent A transdermal or transmucosal preparation that preferably contains 1% by weight and 0.001 to 5.0 of a chelating agent. [Selection figure] None |