| abstract |
Humanized and conjugated antibodies against CD79b useful for the treatment and / or detection of mammalian hematopoietic tumors and methods of using these antibodies for the same purpose. HVR-L1 including a specific sequence A1-A15, HVR-L2 including a specific sequence B1-B7, HVR-L3 including a specific sequence C1-C9, HVR- including a specific sequence D1-D10 Modification of at least one HVR sequence selected from the group consisting of H1, HVR-H2 comprising the specific sequence E1-E18 and HVR-H3 comprising the specific sequence F1-F10, and at least one residue of the specific sequence An anti-CD79b antibody comprising at least one mutant HVR comprising [Selection] Figure 1 |