| abstract |
[PROBLEMS] To provide a human monoclonal antibody molecule, and specifically, the human antibody molecule against human CD81 and a pharmaceutical composition comprising the same as an active ingredient. An antibody against human CD81, which binds to the 80th to 175th region in a specific amino acid sequence. Preferably, an antibody that binds to the 113th to 175th region. An antibody having a binding affinity for a CD81 variant in which a part of the amino acid sequence is substituted is less than 40% when the binding affinity for natural human CD81 is defined as 100%. An antibody that binds to natural human CD81 and has a T cell migration inhibitory action. [Selection figure] None |