| abstract |
Disclosed is a splice switching oligomer (SSO) for a TNF superfamily receptor and a composition comprising the same. A splice switching oligomer comprising at least 10 nucleotides comprises a sequence selected from the group consisting of specific sequences, and a precursor mRNA encoding a receptor selected from human TNFRSF1A and human TNFRSF1B An SSO that can alter the splicing of to produce a stable, secretory, ligand-binding form of the receptor. [Selection] Figure 14 |