abstract |
A nanoparticle comprising a drug, a first block polymer, and a second block polymer is provided. The first block polymer comprises a poly (ethylene oxide) (PEO) block and a polycarbonate block having a side chain aromatic nitrogen-containing heterocycle (N-heterocycle). The N-heterocycle may be in the form of a base, a base hydrogen salt, a base sulfobetaine adduct, or a combination thereof. The second block polymer has a PEO block and a polycarbonate block with side chain catechol groups that can exist as catechol, an oxidized form of catechol or a polymerized form of catechol, or both. The nanoparticles can be dispersed in water and can release the drug in a controlled manner. [Selection] Figure 9 |