| abstract |
A series of substituted imidazo [1,2-b] [1,2,4] triazine derivatives of formula (I) are potent modulators of human TNFα activity and are therefore autoimmune and inflammatory disorders, nerves and nerves. It is useful for the treatment and / or prevention of various human diseases, including degenerative disorders, pain and nociceptive disorders, cardiovascular disorders, metabolic disorders, ocular disorders and oncological disorders. [Selection figure] None |