| abstract |
The invention relates to a glycoprotein comprising a glycan optionally fucosylated according to formula (105) or (106), wherein Su (A) x comprises one or more functional groups A It relates to a glycoprotein. The functional group A is independently selected from the group consisting of a thiol group, a halogen, a sulfonyloxy group, a halogenated acetamide group, a mercaptoacetamide group, and a sulfonated hydroxyacetamide group. The invention also relates to a glycoprotein conjugate in which a glycoprotein according to the invention is conjugated to a molecule of interest. The molecule of interest can be, for example, an active substance. The invention further relates to methods for preparing modified glycoproteins and methods for preparing glycoprotein conjugates. The invention particularly relates to modified antibodies, antibody conjugates, antibody-drug conjugates, and methods for their preparation. [Chemical 1] [Selection] Figure 12 |