| abstract |
The present invention provides antibodies that bind to the extracellular domain of the tyrosine protein kinase transmembrane receptor matriptase. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. Antibody is gastric cancer, colorectal cancer, prostate cancer, breast cancer, ovarian cancer, lung cancer, preferably SCLC, esophageal cancer, head and neck cancer, pancreatic cancer, lymphoma, preferably non-Hodgkin lymphoma and skin cancer Can be used to treat cancers. |