http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016538834-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1037 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-177 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-525 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2014-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2016538834-A |
| titleOfInvention | TRAIL cell membrane permeable peptide-like mutant, its preparation method and application |
| abstract | The present invention mainly relates to the field of drugs by genetic engineering, and in particular, the valine at the 114th site, the glutamic acid at the 116th site in the amino acid sequence at the 114th to 281st site in the extracellular domain of the wild-type TRAIL protein, The glycine at site, the proline at site 119, and the glutamine at site 120 are each mutated to arginine to form amino acids at sites 114-121 in the TRAIL protein into 8 consecutive arginine sequences. And obtaining mutant cDNA sequences by PCR mutation conjugation. A TRAIL mutant is a new generation high-efficiency tumor cell apoptosis-inducing drug having excellent therapeutic action against a plurality of different types of tumors and a very high potential. [Selection] Figure 6 |
| priorityDate | 2013-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 149.