abstract |
The pharmaceutical composition comprises: a) 5 wt% to 95 wt% of the HCl salt of compound (1) .xH 2 O (where x is 0 to 3), based on the weight of the pharmaceutical composition; and b ) 5 wt% to 95 wt% filler based on the weight of the pharmaceutical composition. Another pharmaceutical composition comprises a) compound (1) in water from 1 mg / mL to 20 mg / mL; and b) 0.01M to 0.1M pharmaceutically acceptable pH adjuster. The method of preparing the pharmaceutical composition comprises providing a mixture of compound (1) .compound (1) comprising an HCl salt of xH 2 O and a filler. Another method of preparing the pharmaceutical composition is to form compound (1) in water from 1 mg / mL to 20 mg / mL by mixing the HCl salt of compound (1) .xH 2 O and a pH adjusting agent. Process. Methods for reducing the amount of influenza virus, methods for inhibiting influenza virus replication, and methods for treating influenza each independently use such pharmaceutical compositions. |