http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016535585-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-01008 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-465 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 |
| filingDate | 2014-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2016535585-A |
| titleOfInvention | Method for producing plant-based recombinant butyrylcholinesterase |
| abstract | A novel, reliable, easily scaleable and reproducible method for producing recombinant butyrylcholinesterase (rBuChE) is provided. Through the use of plant transfection procedures, various plant strains can be made under a manufacturing process that can tolerate an effective and scalable amount of rBuChE to produce the desired nerve agent protection requirements (tetramer product). Have been shown to achieve a reliable level of such an enzyme. Moreover, such methods on genetically engineered plant lines produce these enzymes appropriately in tetrameric form, including glycan formation and sialylation (terminal group), to prevent organophosphate exposure. It was shown to enable optimal potency and a proper immunogenic response in plant sources. Thus, the entire production method is encompassed by the present invention, including process steps associated with transfection and production in mammalian cells, and such a reliable supply base from plants. [Selection] Figure 1 |
| priorityDate | 2013-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 534.