| abstract |
A composition for treating an autoimmune disease, allergic disease, or atopic disease comprising a compound that inhibits hyaluronan synthesis and a pharmaceutically acceptable carrier is described. In some embodiments, the compound that inhibits hyaluronan synthesis is 4-methylumbelliferone or a metabolite of 4-methylumbelliferone. A composition having an amount of a compound effective to inhibit hyaluronan synthesis in a mammalian subject for treating autoimmune diabetes, multiple sclerosis and / or autoimmune demyelination, said subject A method comprising the step of administering to is also described. |