abstract |
The present invention provides chimeric FVII molecules comprising FVII, XTEN polypeptides and antibodies that specifically bind to the α and / or β subunits of the non-activated form of GPIIb / IIIIa receptor and antigen binding molecules thereof. To do. The antibody and antigen binding molecule can be genetically fused and / or conjugated to a heterologous moiety, eg, a half-life extending moiety. Furthermore, the present invention includes methods for producing and using these chimeric molecules. |