| abstract |
[Chemical 1] The present invention provides a novel α-vinylcarbonyl corresponding to general formula (I) wherein R 1 , R 2 , R 3 , R 4 , R 5 and Y are as defined in claim 1 Compounds, their isomers, their diastereoisomers and acid addition salts or pharmaceutically acceptable bases. The present invention also relates to a method for producing the compound (I). The invention further relates to the use of said compounds (I) as selective inhibitors of metalloproteases, in particular matrix metalloproteases 12 (MMP-12) and / or 9 (MMP-9). Compound (I) is particularly useful for the prevention and / or treatment of chronic obstructive pulmonary disease (COPD), particularly emphysema caused by tobacco smoke. [Selection figure] None |