| abstract |
The present invention relates to (a) 1 of HA1 domain covalently bonded to the HA1 C-terminal stem segment containing the amino acid of the C-terminal amino acid (including the amino acid) from the y position of the HA1 domain by a binding sequence of 0 to 50 amino acid residues. An influenza hemagglutinin HA1 domain comprising an HA1 N-terminal stem segment comprising amino acids from position to x, preferably p to x, and (b) an influenza hemagglutinin stem domain polypeptide comprising an influenza hemagglutinin HA2 domain comprising HA1 and HA2 Resistant to protease cleavage at the junction between, one or more of the amino acids at positions 337, 340, 352, 353, 402, 406, 409, 413 and / or 416 correspond in the wild-type influenza HA Compared to a position providing the influenza hemagglutinin stem domain polypeptides are mutated. |