| abstract |
The present invention is for the manufacture of a medicament used for the treatment or prevention of recurrence of a disease selected from the group consisting of cancer, psoriasis, psoriatic arthritis, juvenile polyarthritis, rheumatoid arthritis, Crohn's disease, polymyositis, dermatomyositis and sarcoidosis. The use of a dihydrofolate reductase inhibitor selected from the group consisting of methotrexate, trimetrexal, pemetrexed, or a pharmaceutically acceptable salt thereof, wherein said treatment or prevention of recurrence comprises said lipophilic statin and said The dihydrofolate reductase inhibitor is administered to the patient simultaneously, separately or sequentially. The present invention also relates to a pharmaceutical composition comprising a dihydrofolate reductase inhibitor and a lipophilic statin combined with a pharmaceutically acceptable medium and / or excipient. |