| abstract |
The present invention discloses compounds of formula I: [Chemical 1] Wherein R 1a , R 1b , R 2 , R 4 , R 5 , R 6 , R 7 , R 8 , W, X, Y, Z, Cy, and subscript a are defined herein. That's right. The present invention relates to a compound that inhibits autotaxin (NPP2 or ENPP2), a method for producing the compound, a pharmaceutical composition containing the compound, and fibrosis, proliferative disease, inflammatory disease by administering the compound of the present invention, Using the compounds for the prevention and / or treatment of diseases including autoimmune diseases, respiratory diseases, cardiovascular diseases, neurodegenerative diseases, dermatological disorders, and / or diseases associated with abnormal angiogenesis It relates to a treatment method. [Selection figure] None |