abstract |
The present invention relates to general formula (I) BET protein inhibition, particularly BRD4 inhibition, wherein A, X, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and n are each as defined in the specification Dihydroquinoxalinones and dihydropyridopyrazinones, intermediates for the preparation of the compounds of the invention, pharmaceutical compositions comprising the compounds of the invention, and in cases of hyperproliferative disorders, in particular neoplastic disorders Relating to its prophylactic and therapeutic use. The invention further relates to the use of BET protein inhibitors in viral infections, neurodegenerative disorders, inflammatory diseases, atheropathic disorders and male fertility control. [Chemical 1] |