abstract |
The present invention provides highly stable T cell receptors and methods for making and using the same. Mutations occurred in the hydrophobic core region of the T cell receptor (TCR) of the present invention, leading to improved stability. The TCR of the present invention can be used not only for the study of the interaction between TCR and pMHC (peptide-major histocompatibility complex), but also for the diagnosis and treatment of disease. |