| abstract |
The present invention relates to novel compounds of formula (I) and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopes thereof. Body-labeled derivatives, prodrugs, and pharmaceutical compositions are provided. The present invention also treats and / or prevents neurodegenerative diseases to treat and / or prevent diseases associated with protein aggregation such as amyloidosis (eg, Parkinson's disease and Alzheimer's disease) in a subject in need. For the treatment and / or prevention of diseases associated with the TarDNA binding protein 43 kDa, for reducing or preventing protein aggregation, or for modulating E3 ubiquitin ligase And methods and kits using the pharmaceutical compositions are provided. |