| abstract |
An implantable biomedical device with reduced fibrous hyperproliferation around the capsule is disclosed. The device comprises a biocompatible material and has certain features that reduce the induction of a fibrotic response after implantation than the same device that lacks one or more of these features present in the device. be able to. Disclosed are biocompatible hydrogel capsules that encapsulate mammalian cells, have a diameter greater than 1 mm, and optionally have a cell-free core, and reduce fibrous hyperproliferation after implantation into a subject. Also disclosed is a method of treating a disease in a subject comprising administering to the subject a therapeutically effective amount of the disclosed encapsulated cells. |