| abstract |
12-hour antitussive comprising benzonate in a matrix comprising an amount of one or more pharmaceutically acceptable modified-release pH-independent substances sufficient to impart a 12-hour modified release profile to benzonate A modified-release solid tablet or capsule that is substantially free of benzonate release from the tablet or capsule in the oral cavity and has a release of about 25 benzonate within an hour as measured by an in vitro dissolution assay. Is described for a 12-hour antitussive modified release solid tablet or capsule. Modified release is achieved by (a) a water-insoluble wax or waxy material with a high melting temperature, (b) a low viscosity hydrophilic polymer (eg, hydroxypropyl methylcellulose), (c) a reverse enteric coating, or a combination thereof. Can be granted. The benzonate can be in an adsorbent material comprising silica or silicate, or in a complex comprising a weakly acidic ion exchange resin complex. |