| abstract |
The present invention provides compositions and methods relating to or derived from an antigen binding protein that can inhibit the binding of PCSK9 to LDLR. In embodiments, the antigen binding protein specifically binds to PCSK9. In some embodiments, the antigen binding protein is a fully human antibody, a humanized antibody or a chimeric antibody, binding fragments and derivatives of such antibodies, and a polypeptide that specifically binds to PCSK9. Other embodiments include such antigen binding proteins and fragments and derivatives thereof, as well as polypeptides, nucleic acids encoding cells comprising such polynucleotides, as well as such antigen binding proteins and fragments and derivatives thereof, And methods for using such antigen-binding proteins, fragments and derivatives thereof, and polypeptides, including methods for producing polypeptides, and methods for treating or diagnosing subjects suffering from hypercholesterolemia and related diseases or conditions, I will provide a. |