| abstract |
Disclosed are compositions and methods for novel plasmin inhibitory polypeptides that are structural variants of the first inhibitor domain (KD1) of human TFPI-2 Kunitz-type proteinase. The polypeptide is a potent plasmin inhibitor, and in certain embodiments has antifibrinolytic activity and / or reduced anticoagulant activity compared to wild type TFPI-2 KD1, and is a highly immunogenic agent. Does not show sex. In addition to use as an anticancer agent, antifibrinolytic agent, protease inhibitor, the plasmin inhibitory polypeptide is expected to find use in other situations. |