http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016514149-A
Outgoing Links
Predicate | Object |
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classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6889 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6855 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6851 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-5517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-16 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5517 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 |
filingDate | 2014-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2016-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2016514149-A |
titleOfInvention | Pyrrolobenzodiazepine and its conjugates |
abstract | Conjugate compounds of formula (A): (Where R 2 is Wherein R 36a and R 36b are independently selected from H, F, C 1-4 saturated alkyl, C 2-3 alkenyl, wherein the alkyl and alkenyl groups are C 1-4 alkylamide and Optionally substituted by a group selected from C 1-4 alkyl esters; Or when one of R 36a and R 36b is H, the other is selected from a nitrile and a C 1-4 alkyl ester; R 6 and R 9 are independently selected from H, R, OH, OR, SH, SR, NH 2 , NHR, NRR ′, NO 2 , Me 3 Sn and halo; R 7 is independently selected from H, R, OH, OR, SH, SR, NH 2 , NHR, NRR ′, NO 2 , Me 3 Sn and halo; Y is selected from the formulas A1, A2, A3, A4, A5 and A6: L is a linker attached to a cell binding factor; CBA is a cell binding factor; n is an integer selected from 0 to 48; R A4 is a C 1-6 alkylene group (A) R 10 is H, R 11 is OH, OR A , where R A is C 1-4 alkyl; or (b) R 10 and R 11 are attached to each other; A nitrogen-carbon double bond is formed between the nitrogen atom and the carbon atom; or (c) R 10 is H and R 11 is OSO z M, wherein z is 2 or 3 And M is a monovalent pharmaceutically acceptable cation; R and R ′ are each independently selected from an optionally substituted C 1-12 alkyl group, a C 3-20 heterocyclyl group and a C 5-20 aryl group, optionally with respect to the group NRR ′, R and R ′ Together with the nitrogen atom to which they are attached form an optionally substituted 4-, 5-, 6- or 7-membered heterocycle; In which R 16 , R 17 , R 19 , R 20 , R 21 and R 22 are as defined for R 6 , R 7 , R 9 , R 10 , R 11 and R 2 , respectively; Where Z is CH or N; Wherein T and T ′ are independently selected from a single bond or C 1-9 alkylene, wherein the alkylene chain is interrupted by one or more heteroatoms such as O, S, N (H), NMe. Provided that the number of atoms in the shortest atomic chain between X and X ′ is 3-12 atoms; X and X ′ are independently selected from O, S and N (H). ). |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2022516911-A |
priorityDate | 2013-03-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1052.