abstract |
The present invention is directed to compounds of formula (I): [Chemical 1] Where The present invention is directed to compounds of formula (I): Where n is an integer of 0 to 1, when n is 0, X is CH 2 ; when n is 1, X is CH 2 or oxygen; R 1 is phenyl or pyridinyl, which may be optionally substituted by 1 to 4 substituents independently selected from halogen and alkyl; and R 2 is phenyl, pyridinyl, Pyrazinyl, pyrazinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl, or thiophenyl, wherein phenyl, pyridinyl, pyrazinyl, pyrazidinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl, or thiophenyl are independently selected from the group consisting of halogen, alkyl, hydroxy, and alkoxy Optionally substituted by 1 to 2 substituents selected. The invention also relates to a pharmaceutical composition comprising a compound of formula (I). The compounds of formula (I) are useful as P2X7 modulators. |