| abstract |
The present invention generally relates to transdermal delivery of fluticasone and other glucocorticoids. In some embodiments, transdermal delivery can be facilitated by the use of harsh biophysical environments, such as high ionic strength environments. According to one set of embodiments, a transdermal delivery composition is provided comprising fluticasone and / or a salt thereof, and optionally a nitric oxide donor. Other glucocorticoids can also be used in some cases. Such compositions can be used to facilitate delivery of an effective amount of fluticasone or other glucocorticoids, not only locally or superficially, but to the whole body or deeper tissues, and in some cases The effects of fluticasone or other corticoids can be extended for unexpectedly long periods of time, such as days or weeks. |