| abstract |
The invention provides cancer stem cells and compounds of formula I as inhibitors of cancer stem cell pathway kinases and other related kinases, pharmaceutical compositions and their use in the treatment of cancer or related disorders in mammals. Wherein, in particular, R 2 is an optionally substituted heterocycle, or an optionally substituted aryl, and one of R 4 , R 5 , R 6 and R 7 is substituted Heterocycle or substituted aryl. Also provided is a pharmaceutical composition comprising a compound of the invention, or a pharmaceutically acceptable salt, ester or prodrug thereof, and a pharmaceutically acceptable excipient, carrier or diluent. |