| abstract |
Compounds that modulate the physiological effects of the proprotein convertase subtilisin / kexin type 9 (PCSK9) and the treatment of cardiovascular disease (CVD) to reduce LDL cholesterol levels and / or including hypercholesterolemia and / or Alternatively, therapeutic methods for the use of the compounds for prevention are described. Examples of compounds include thiadiazole derivatives, isoxazole derivatives, 1,2,4-triazole derivatives, thiazole derivatives, indole derivatives, pyrazole derivatives and pyrrolinone derivatives. |