| abstract |
The present disclosure describes compositions and methods involved in tumor suppression and inhibition of cell infection by pathogens. Generally, the composition comprises mRNA cargo that can provide a therapeutic benefit after being introduced into epithelial cells. In some cases, the mRNA can encode a polypeptide. In some cases, the polypeptide can inhibit epithelial cell proliferation. In other embodiments, the polypeptide may be involved in innate immunity. In various embodiments, the polypeptide may comprise cathelicidin antibacterial protein (CAMP), calprotectin, S100A8, S100A9, β-defensin, S100A7, secretory leukocyte inhibitor, lipocalin 2, or lysozyme. In some embodiments, the mRNA can include a stabilizing moiety such as, for example, a 5 ′ cap or a 3 ′ extension. |