abstract |
Provided herein, an immune cell, such as a T lymphocyte, can be directed to a target antigen and when the antigen binds to a polypeptide, the T cell is expanded or the antigen is A therapeutic polypeptide, such as a chimeric antigen receptor, that can kill cells for presentation. Here, the polypeptide includes a transmembrane domain derived from a T cell co-inhibitory protein such as CTLA4 or PD-1. Also provided herein are T lymphocytes that express the polypeptide and the use of such T lymphocytes to treat diseases such as cancer. [Selection] Figure 1 |