| abstract |
The present invention discloses a complex of a glucose derivative and proline, a crystal, a production method and application thereof. When the diffraction angle of the eutectic is 2θ, the characteristic peaks are 4.339, 11.499, 12.835, 13.921, 15.294, 16.212, 16.804, 17.154, 18.335, 19.274, 19.982, Including 22.710, 23.218, 24.885, 27.940, 29.612 and 30.313, the error range of 2θ is ± 0.1. In the corresponding production method, the compound A solution and the L-proline solution are mixed, cooled and crystallized. The present invention also provides the use of the crystalline form during drug manufacture. The eutectic in the present invention has high water solubility, low hygroscopicity, high stability, and is suitable for producing various preparations. |