| abstract |
The present invention relates, in part, to compositions and methods that use peptide tags that bind to hyaluronan (HA). The HA tag can bind to a molecule, eg, a protein or nucleic acid, when administered to the eye, increases half-life and / or average residence time in the eye, and / or in the eye of the protein or nucleic acid. This leads to a decrease in clearance. The invention also encompasses a method for treating an ocular disease, eg, retinal vascular disease, by administering a protein or nucleic acid linked to an HA peptide tag. [Selection figure] None |