| abstract |
The present invention relates to 2'-alkynyl substituted nucleoside derivatives of formula (I) and pharmaceutically acceptable salts thereof. In the formula, B, X, R1, R2, R3 and R4 are as defined in the present specification. The present invention also relates to compositions comprising at least one 2'-alkynyl substituted nucleoside derivative and methods of using said 2'-alkynyl substituted nucleoside derivative to treat or prevent HCV infection in a patient. [Chemical 1] [Selection figure] None |